Results Following Hypothermic Asanguineous Liver Perfusion in Dogs

Liver preservation by single passage hypothermic "squirt" perfusion.

A single passage, hypothermic, intermittent squirt perfusion of the pig's liver is described which has allowed preservation of porcine livers for up to 17 hours. After preservation, orthotopically allografted livers can maintain recipient animals in good health. If this technique can be applied to clinical liver transplantation it should be possible to move livers from one hospital to another i...

Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application

Dynamic preservation strategies such as hypothermic machine perfusion are increasingly discussed to improve liver graft quality before transplantation. This review summarizes current knowledge of this perfusion technique for liver preservation. We discuss optimization of perfusion conditions and current strategies to assess graft quality during cold perfusion. Next, we provide an overview of po...

The Groningen Hypothermic Liver Perfusion Pump: Functional Evaluation of a New Machine Perfusion System

The Groningen Hypothermic Liver Perfusion Pump: Functional Evaluation of a New Machine Perfusion System

The technique of hypothermic perfusion.

The machine described is in commercial production although the perfusions, to date, were performed with the prototype described by Ross (1960a). The extracorporeal circuit is mounted on the front of the machine (Fig. 1) under the vision of the perfusionist and comprises: Coronary suction reservoir (A) into which all wound and coronary sinus blood is returned by suction from a horizontally mount...